DoseRight® Syringe Clips

 


A simple, low-cost product that improves accurate dosing of liquid medications

Need

Misdosing of liquid medications is a common occurence and can have serious consequences.

A range of medications are administered in liquid form, including Anti-Retroviral medications (ARVs) for HIV-positive infants and children. Delivering the accurate dose of medication is critical to ensure proper treatment and prevent viral resistance. The risk of misdosing ARVs is heightened by complicated drug regimens, which change as the child grows. Studies show that 40-60% of parents make errors when giving children liquid medication.1, 2
In regions where HIV/AIDS rates are highest and education rates are low, caregivers may lack literacy and numeracy skills and therefore struggle to administer the correct dosages of ARVs. Popular over-the-counter liquid medications contain variable, and often inconsistent, dosing directions and devices. When oral syringes are not available, spoons and measuring cups are a common method for measuring the dosage of these medicines. Even in the hands of a seasoned professional, these measuring tools can be inaccurate.

Design

The DoseRight Syringe Clip is a small plastic clip that fits into the barrel of an oral dosing syringe. It serves as a guide to assist the caregiver in delivering an accurate dose of liquid medication.

Simple

The DoseRight Syringe Clips can be affixed by a healthcare professional, caregiver, or the patient themselves. Thus, they provide a simple method for accurate medicine administration regardless of literacy level, visual acuity, or manual dexterity.

Accurate

The DoseRight Syringe Clip acts as a stopping mechanism that presets to the correct dose without ever contacting the medication. Evaluations in Houston and Malawi have shown that the DoseRight Syringe Clip improves dosing accuracy.3

Low-cost

The DoseRight Syringe Clips were originally designed for low-resource settings, and their simple design allows for cost-effective manufacturing. DoseRight Syringe Clips are multi-use and can be reused for the same dosage amount given to the same patient.

Easy to use

The DoseRight Syringe Clips are made of polypropylene and range in dosing volume from 0.5mL to 5.0mL in half mL graduations. They are embossed with the dosage achieved by the specific Clip. The Clips are color coded so users can easily differentiate the size and dosage.

The DoseRight Syringe Clips are also useful for high-accuracy drug delivery applications. The DoseRight Syringe Clip is designed specifically to work with certain syringe brands and models. The current model of DoseRight Syringe Clip is compatible with a Becton-Dickinson™ Brand, 5mL Oral Syringe. The syringe is sold separately. The DoseRight Syringe Clips are packaged in small bags of quantity 20 and provided at the dosage levels required by the program using them. To discuss specific program requirements please contact us directly. The DoseRight Syringe Clips are patent pending.

Instructions

To the left is a brief instructional video explaining the proper use of the DoseRight Syringe Clips.

For a PDF version of the installation instructions, click here.

Impact

DoseRight Syringe Clips were originally developed by a team of students at Rice University in the Beyond Traditional Borders program. In 2010, the students demonstrated the clips to pharmacists and pediatricians caring for HIV-infected children in Swaziland.

In partnership with Rice360° Institute for Global Health Technologies, the Swaziland Ministry of Health, and the Clinton Health Access Initiative, more than 213,000 syringe clips have been delivered to Swaziland, where they are being used by nearly 12,000 participants in the national Prevention of Mother to Child Transmission of HIV/AIDS (PMTCT) program to facilitate the accurate dosage of liquid antiretroviral medication to help prevent the transmission of the virus from mothers to children.

I was starting a child on a new ARV here in Swaziland, that is dosed with liquid.  Without even asking, our pharmacy here at Baylor has been automatically dispensing the appropriately sized clip for the child!!  I was so excited to see that the clips are being used appropriately!  (really…its the small things)!

Dr. Stephanie Marton

October 2012, Baylor College of Medicine

Interested in the DoseRight Syringe Clips?

The DoseRight Syringe Clips are currently being distributed in GAVI Alliance countries and other developing country sites where there is an appropriate need for accuracy in oral delivery of medication. The DoseRight Syringe Clips can be provided to supporting organizations such as Ministries of Health or Non-Governmental Organizations engaged in conducting large scale pediatric treatment programs. The DoseRight Syringe Clips are particularly appropriate for programs working in the field of the Prevention of Mother to Child Transmission of HIV (PMTCT).

The DoseRight Syringe Clips are also currently for retail sale in the USA. Please contact us for additional information regarding your specific DoseRight Syringe Clip application.

Contact Us

(1) Simon HK, Weinkle DA. Over‐the‐counter medications: do parents give what they intend to give? Arch Pediatr Adolesc Med. 1997;151(7):654–656.
(2) Yin HS, Dreyer BP, Van Schaick L, Foltin GL, Dinglas C, Mendelsohn AL. Randomized controlled trial of a pictogram‐based intervention to reduce liquid medication dosing errors and improve adherence among caregivers of young children. Arch Pediatr Adolesc Med. 2008; 162(9):814‐ 822.
(3) Spiegel GJ, Dinh C, Gutierrez A, Lukomnik J, Lu B, Shah K, Slough T, Yeh PT, Mirabal Y, Gray LV, Marton S, Adler M, Schutze GE, Wickham H, Oden M, Richards-Kortum R. Design, evaluation, and dissemination of plastic syringe clip to improve dosing accuracy of liquid medications. Ann Biomed Eng. 2013; 41(9):1860-1868.